your hands. Underneath 
preferablyGood question. Breasts are made of fat contained within a covering of skin. If left unsupported they sag and stretch the skin. A means of support is required. Various devices can be used. Men will offer to hold them up for you but that may not be a long term solution. So how can you hold up a really big pair of tits?
You can
use your hands. Underneath preferably
Practice at home or ...
...in the local baths - the added buoyancy can help
Really big? Use your arms as well
Friends will often
help 
Girls
with 
big nipples can use their 
finger tips
The main thing is to feel comfortable with your own body and develop your own technique. The problem is, however, that no matter how competent you become at manual breast maintenance one day you will need to open a door
Opening doors is a big problem
That's why
the search started for a more convenient means of support.
Some way of holding up breasts
that enabled girls to walk around without having to worry about
embarrassing mishaps.
Ingenious, but made conversation difficult
String
or 
even chains through 
the nipples
Clever but impracticable
Superb
uplift 
and very popular 
with gentlemen
None of these techniques provided a long term solution, however, and the bra was invented (short for brassiere - that's a French word - sex was invented by the French and so many of the words come from France).
The first bra was made of wood
Early
cloth 
bras were only a 
little better
Under breast support was needed
Designs improved but often failed
under extreme loads
The designers persevered and finally after years of hard work the hi-tech bra was born. Modern women have the benefit of ...
Uplift and Support 
Of course not all women choose to take advantage of high technology but most do.
Some
girls 
prefer to plough their 
own furrow
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